stefan: Du überforderst die Forenteilnehmer. Arthrose oder Arthritis, das ist für die doch alles dasselbe: Aua im Gelenk. Das darfst Du nicht so penibel sehen.
Du kommst sonst in den Ruf Fachwissen zu besitzen. Wird hier unter den Laien nicht gern gesehen. (Ironie kann ich auch.)

Zuletzt bearbeitet am 15.02.13 12:15

Moin Stefan,
ausnahmsweise will ich unter uns Pfarrerstöchtern noch einen kurzen Tipp geben. Bei Arthrose soll Glucosamin in Kombination mit Chondroitin hervorragende Erfolge zeitigen. Der Schulmediziner Prof. Dr. Wittenberg, Chefarzt der Orthopädie Herten, mehrfacher Deutscher Meister in seiner Alterklasse diverser Radrenndisziplinen und Organisator der "Ruhrsportwochen" hat persönlich beste Erfahruingen damit gemacht. Großer Nachteil dieser Nahrungsergänzungsmittel: Kontraindikation bei MD und ML.

Gruss Gerdos

Potential conflict with glucosamine/chondroitin and anticonvulsants

Some people, especially when in their middle years and their joints are packing up, take glucosamine and chondroitin to build up new collagen in their joints and reduce inflammation. We cannot judge the effectiveness of these supplements for improving joints or for relieving osteoporosis (you might e. g. read quackwatch for more information or have a look at D.O. Clegg at al. "Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis" New Engl J Med. 354 (2006) p 795–808. PMID 16495392 ). But occasionally Dupuytren's patients report that taking glucosamine / chondroitin triggered quick growth of their Dupuytren's nodules and stopping it reduced those nodules. So, if you suffer from Dupuytren's or Ledderhose, it might make sense to watch out for accelerated growth of the nodules if you are taking glucosamine. Comments from a patient are posted in our forum, another example would be e.g. dup_clucosamine_UK.

Specific antiepileptica, i.e. anticonvulsant medication like phenobarbital (brand name e.g. Luminal), can possibly trigger Dupuytren's and Ledderhose disease (and other diseases like Sudeck's syndrome and polyfibromatosis). See: J. Rothmeier and W. Froscher "Connective tissue changes during longterm anticonvulsive therapy" Fortschritte der Medizin 107(1989) p743-747 und P. Coral et al. "Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants" Arquivos de Neuro-Psiquiatria. 57(1999) p 860-862. Adam Strzelczyk, Heinrich Vogt, Hajo M. Hamer, and Günter Krämer "Continuous phenobarbital treatment leads to recurrent plantar fibromatosis" Epilepsia May 2008 abstract conclude "that patient groups ... develop Ledderhose syndrome or other associated syndromes as Dupuytren's contractures, frozen shoulder, Peyronie's disease or complex regional pain syndrome in the course of phenobarbital treatment." - There is also a topic on "Phenobarbetol" in our forum.

While the link with with phenobarbital seems to be established, there is much less evidence that phenytoin (brand name e.g. Dilatin) can trigger Dupuytren's contracture or Ledderhose disease. We also want to mention the study by J.M. Geoghegan et al. "Dupuytren's disease risk factors" J. Hand Surg. [Br] 29 (2004) p 423-6, which does not find any relation to anti-epileptic medications but a strong relation to diabetes and specifically to insulin controlled diabetes (not as strong if diet controlled) Duypuytrens_risk_factors.